Main Street Inn B&B

Sainte Genevieve, Missouri

Main Street Inn B&B

Sainte Genevieve, Missouri

Main Street Inn B&B

Sainte Genevieve, Missouri

Main Street Inn B&B

Sainte Genevieve, Missouri

A Historic Bed & Breakfast Built in 1882


Originally built in 1882, as the Meyer Hotel, the Main Street Inn B&B has long been considered one of Missouri’s finest bed and breakfast establishments. Having undergone and completed an extensive renovation and reopening in 2017, the Main Street Inn B&B’s proprietors, Susan O’Donnell and Patrick Fahey would like to welcome you to what we hope will be a truly wonderful, relaxing and memorable experience.

The Main Street Inn B&B has eight rooms, each with a distinctive design, private baths, eco-friendly toiletries, hair dryers, irons, fine linens, seating areas and complimentary WiFi. We are also pleased to offer a pet-friendly room, located on our first floor with a private side entry, for those people who love to travel with their faithful companion.

Located in the heart of Sainte Genevieve’s Historic District, and surrounded by beautiful wine country, we are just a short one-hour drive from both St. Louis and Cape Girardeau, five hours from Chicago and just a little over four hours from Nashville.

 If you are looking for the perfect place to book any of the following...

Family Reunions

Weddings Parties

Romantic Getaways



Girl's Weekends

and more...

...the Main Street Inn B&B is the perfect destination.

August 2019 Special

Use the code Summer2019 and enjoy 20% off of a stay in August, Sundays through Thursdays! 

This special is subject to availability. Arrival date must be in August of 2019.

20% Off August
North Parlor Game Room
North Parlor North Parlor Dining Room 2nd Floor Porch



 A full Breakfast is served every morning between 9:00am and 10:30am, with early morning coffee available on all three floors by 7:00am, for the early risers.

Each evening of your stay, you are invited to attend a simple wine reception from 5:00pm to 7:00pm in the North Parlor.



Our Rooms

How to Find Us

221 North Main Street, Sainte Genevieve, Missouri 63670

Trip_advisor Reviews

Guest Reviews

We strive to provide an exceptional level of service for every guest, and are proud to have a 4.5-star rating on TripAdvisor.

View Reviews