A Historic Bed & Breakfast Built in 1882
Originally built in 1882, as the Meyer Hotel, the Main Street Inn B&B has long been considered one of Missouri’s finest bed and breakfast establishments.
Having recently undergone an extensive year-long renovation, Proprietors, Susan O’Donnell and Patrick Fahey, along with Innkeeper, Jean Marie Rozier Sellberg, are thrilled to re-open the Main Street Inn B&B and welcome our guests to what we hope will be a truly wonderful experience.
Located in the heart of Sainte Genevieve’s Historic District, and surrounded by beautiful wine country, we are just a short one-hour drive from both St. Louis and Cape Girardeau, five hours from Chicago and just a little over four hours from Nashville.
If you are looking for a relaxing and peaceful getaway, the Main Street Inn B&B is the perfect destination.
FOR OUR GUESTS
A full Breakfast is served every morning between 9:00am and 10:30am, with early morning coffee available on all three floors by 7:00am, for the early risers.
Each evening of your stay, you are invited to attend a simple wine reception from 6:00pm to 7:00pm in the North Parlor.
How to Find Us
221 North Main Street, Sainte Genevieve, Missouri 63670
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We strive to provide an exceptional level of service for every guest, and are proud to have a 4.5-star rating on TripAdvisor.View Reviews