Main Street Inn B&B

Sainte Genevieve, Missouri

Main Street Inn B&B

Sainte Genevieve, Missouri

Main Street Inn B&B

Sainte Genevieve, Missouri

Main Street Inn B&B

Sainte Genevieve, Missouri

A Historic Bed & Breakfast Built in 1882

Originally built in 1882, as the Meyer Hotel, the Main Street Inn B&B has long been considered one of Missouri’s finest bed and breakfast establishments.

Having undergone an extensive year-long renovation, the Main Street Inn B&B re-opened during the Summer of 2017. Proprietors, Susan O’Donnell and Patrick Fahey, along with Innkeeper, Terri Scott, are more than thrilled to welcome our guests and treat them to what we hope will be a truly wonderful experience.

Located in the heart of Sainte Genevieve’s Historic District, and surrounded by beautiful wine country, we are just a short one-hour drive from both St. Louis and Cape Girardeau, five hours from Chicago and just a little over four hours from Nashville.

 If you are looking for the perfect place to book any of the following...

Family Reunions

Weddings Parties

Romantic Getaways



Girl's Weekends

and more...

...the Main Street Inn B&B is the perfect destination.

Weekday Business Rate

Sundays through Thursdays

25% Off Sunday through Thursday (single occupancy only). Use Promo Code: "BUSINESS" when booking.

Weekday Business Discount

Holiday Christmas Festival

Our Gift to You!


Holiday Christmas Festival Special
North Parlor Game Room
North Parlor North Parlor Dining Room 2nd Floor Porch


A full Breakfast is served every morning between 9:00am and 10:30am, with early morning coffee available on all three floors by 7:00am, for the early risers.

Each evening of your stay, you are invited to attend a simple wine reception from 6:00pm to 7:00pm in the North Parlor.



Our Rooms

How to Find Us

221 North Main Street, Sainte Genevieve, Missouri 63670

Trip_advisor Reviews

Guest Reviews

We strive to provide an exceptional level of service for every guest, and are proud to have a 4.5-star rating on TripAdvisor.

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